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Plasma androstenedione and oestrone concentrations were measured in 72 postmenopasual women. The women included some who had undergone oophorectomy, some with osteoporosis, and normal controls; they were matched for years since menopause. Both hormone concentrations were significantly reduced in the women with osteoporosis. The women who had undergone oophorectomy had hormone concentrations intermediate between the normal and osteoporotic values. Oestrogen deficiency secondary to low androstenedione levels is a major risk factor in postmenopausal osteoporosis, and may be caused by failure of ovarian stromal androgen secretion or some abnormality in the pituitary-adrenal axis.
D H Marshall, and
R G Crilly, and
B E Nordin
December 1974,
Folia endocrinologica,
D H Marshall, and
R G Crilly, and
B E Nordin
January 1979,
British journal of obstetrics and gynaecology,
D H Marshall, and
R G Crilly, and
B E Nordin
April 1984,
Maturitas,
D H Marshall, and
R G Crilly, and
B E Nordin
February 1978,
Clinical science and molecular medicine,
D H Marshall, and
R G Crilly, and
B E Nordin
March 1981,
Maturitas,
D H Marshall, and
R G Crilly, and
B E Nordin
November 1978,
The Journal of endocrinology,
D H Marshall, and
R G Crilly, and
B E Nordin
January 2009,
Rheumatology international,
D H Marshall, and
R G Crilly, and
B E Nordin
April 1982,
Maturitas,
D H Marshall, and
R G Crilly, and
B E Nordin
July 1978,
Acta endocrinologica,
D H Marshall, and
R G Crilly, and
B E Nordin
October 1991,
Calcified tissue international,
