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We measured basal plasma prolactin concentrations (in samples obtained during the early follicular phase) in 25 normal (control) women and in a similar group of 40 patients with a long-standing history of infertility. The infertile patients were all ovulating regularly, and had been unsuccessfully treated with clomiphene and in some cases dydrogesterone and human menopausal gonadotrophin. Although none of the patients had plasma prolactin concentrations greater than 1000 muU/ml, 47.5% of the estimations were greater than 1 standard deviation (SD) above the mean established for our control group. This difference was highly significant (P less than 0.001). Treatment with various bromocriptine regimens effectively reduced prolactin concentrations to below normal in all cases, and 16 pregnancies followed-13 during bromocriptine treatment and three in the first post-treatment cycle. The cumulative conception rate was 63.4% after 10 months' treatment.
E A Lenton, and
O S Sobowale, and
I D Cooke
November 1977,
Lakartidningen,
E A Lenton, and
O S Sobowale, and
I D Cooke
March 1978,
Clinical endocrinology,
E A Lenton, and
O S Sobowale, and
I D Cooke
January 1984,
Acta obstetricia et gynecologica Scandinavica,
E A Lenton, and
O S Sobowale, and
I D Cooke
December 1998,
Ginekologia polska,
E A Lenton, and
O S Sobowale, and
I D Cooke
April 1981,
European journal of obstetrics, gynecology, and reproductive biology,
E A Lenton, and
O S Sobowale, and
I D Cooke
February 2009,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
E A Lenton, and
O S Sobowale, and
I D Cooke
May 1988,
Human reproduction (Oxford, England),
E A Lenton, and
O S Sobowale, and
I D Cooke
December 1985,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
E A Lenton, and
O S Sobowale, and
I D Cooke
November 1987,
Fertility and sterility,
E A Lenton, and
O S Sobowale, and
I D Cooke
July 1982,
American journal of obstetrics and gynecology,
