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Non-allergic bronchial hyper-reactivity is a feature of most patients with asthma. We have measured non-allergic bronchial reactivity to inhaled histamine and methacholine in thirteen asthmatic subjects before and after allergen inhalation in the laboratory. The allergen inhalation produced mild early asthmatic responses (19-40% FEV1 fall) in all thirteen, additional definite late asthmatic responses (17-29% FEV1 fall) in four, and equivocal late asthmatic responses (5-11% FEV1 fall) in five. Following allergen inhalation, non-allergic bronchial reactivity increased in seven for up to 7 days. The seven included all four with definite late asthmatic responses and three of the five with equivocal late asthmatic responses. We conclude that allergens make asthma worse, partly through non-allergic mechanisms, and that avoidance of allergens is important in reducing non-allergic bronchial hyper-reactivity.
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
February 1987,
The Journal of allergy and clinical immunology,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
April 1975,
Vnitrni lekarstvi,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
May 1976,
Clinical allergy,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
January 1995,
Pneumonologia i alergologia polska,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
February 2011,
Journal of aerosol medicine and pulmonary drug delivery,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
April 2001,
The Science of the total environment,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
September 1988,
Journal of applied physiology (Bethesda, Md. : 1985),
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
July 2010,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
January 1999,
Allergy,
D W Cockcroft, and
R E Ruffin, and
J Dolovich, and
F E Hargreave
April 1993,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
