-transparent.png){kind=logo}
The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg-kg-1 and 0.3 mg-kg-1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.
Related Publications
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
November 1978,
The Journal of pharmacy and pharmacology,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
August 1981,
Journal of pharmacokinetics and biopharmaceutics,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
October 1986,
Journal of pharmacokinetics and biopharmaceutics,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
May 1979,
Clinical pharmacology and therapeutics,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
June 1979,
The Journal of pediatrics,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
January 1983,
Pharmacology & therapeutics,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
January 1986,
Journal of clinical pharmacology,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
January 1985,
European journal of clinical pharmacology,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
January 1986,
European journal of clinical pharmacology,
M E Pickup, and
J R Lowe, and
P A Leatham, and
V M Rhind, and
V Wright, and
W W Downie
January 1986,
European journal of clinical pharmacology,
