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Nine offspring of two diabetic parents and 18 normals were studied with two intravenous glucose loads (o.5 gm./kg. body weight), 60 minutes apart. By thus stressing the beta cell, subtle defects could be identified in the prediabetics: (1) An inverse relationship between insulin peak response and insulin concentration 60 minutes postglucose was seen, a phenomenon exactly the opposite to that seen in normals. (2) Insulin peak response was delayed slightly after the first pulse and significantly after the second. (3) A less effective handling of the glucose load when compared with normals was brought out by the second stimulation. (4) There was a significant reduction in the insulin response per unit change in glucose after the first glucose pulse that was accentuated after the second pulse. This double-stimulation technique amplifies previously detected slight but significant defects in insulin secretion that might help to identify a diabetes-prone population.
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
December 1969,
The Journal of clinical endocrinology and metabolism,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
April 1990,
The Journal of the Association of Physicians of India,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
May 1977,
Diabetes,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
October 1997,
Metabolism: clinical and experimental,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
February 2000,
The Journal of the Association of Physicians of India,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
January 1986,
Pancreas,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
November 1988,
The New England journal of medicine,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
May 1989,
The New England journal of medicine,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
January 1967,
Diabetes,
L Koncz, and
J S Soeldner, and
H Otto, and
T M Smith, and
R E Gleason
May 1967,
Lancet (London, England),
