BIOMAT Database Logo BIOMAT Database Logo

The metabolism of drugs by hepatic microsomal enzymes. Studies on intramicrosomal distribution of enzymes and relationships between enzyme activity and structure of the hepatic endoplasmic reticulum. 1966

J R Fouts, and L A Rogers, and T E Gram

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D008861 Microsomes Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) Microsome
D010088 Oxidoreductases The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9) Dehydrogenases,Oxidases,Oxidoreductase,Reductases,Dehydrogenase,Oxidase,Reductase
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D003061 Codeine An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough. Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-,Ardinex,Codeine Phosphate,Isocodeine,N-Methylmorphine,N Methylmorphine
D004721 Endoplasmic Reticulum A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed) Ergastoplasm,Reticulum, Endoplasmic
D000632 Aminopyrine A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS. Amidophenazon,Aminophenazone,Dimethylaminophenazone,Dipyrine,Amidazophen,Amidophen,Amidopyrine,Aminofenazone,Dimethyl-N-aminoantipyrine,Dimethylaminoantipyrine,Eufibron,Dimethyl N aminoantipyrine
D000661 Amphetamine A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. Desoxynorephedrin,Levoamphetamine,Phenopromin,l-Amphetamine,Amfetamine,Amphetamine Sulfate,Amphetamine Sulfate (2:1),Centramina,Fenamine,Mydrial,Phenamine,Thyramine,levo-Amphetamine,Sulfate, Amphetamine,l Amphetamine,levo Amphetamine
D000814 Aniline Compounds Compounds that include the aminobenzene structure. Phenylamine,Phenylamines,Anilines,Compounds, Aniline

Related Publications

J R Fouts, and L A Rogers, and T E Gram
Lack of enhanced microsomal enzyme activity by oxandrolone, an inducer of hepatic smooth endoplasmic reticulum.
July 1976, Biochemical pharmacology,
J R Fouts, and L A Rogers, and T E Gram
Structure-activity relationships for the induction and inhibition of hepatic microsomal enzymes in the rat by organohalogen compounds.
November 1972, The Biochemical journal,
J R Fouts, and L A Rogers, and T E Gram
[Effect of thiamine on the activity of liver endoplasmic reticulum enzymes metabolizing drugs].
January 1979, Farmakologiia i toksikologiia,
J R Fouts, and L A Rogers, and T E Gram
Influence of drugs and chemical upon hepatic enzymes and proteins-I. Structure-activity relationship between various barbiturates and microsomal enzyme induction in rat liver.
March 1976, Biochemical pharmacology,
J R Fouts, and L A Rogers, and T E Gram
Testosterone metabolism by hexachlorobenzene-induced hepatic microsomal enzymes.
December 1979, American journal of veterinary research,
J R Fouts, and L A Rogers, and T E Gram
Influence of steroid distribution between microsomes and soluble fraction on steroid metabolism by microsomal enzymes.
September 1969, Endocrinology,
J R Fouts, and L A Rogers, and T E Gram
Studies of metabolism of tripamide, a new antihypertensive agent. II. Metabolism by the hepatic microsomal enzymes.
October 1981, Xenobiotica; the fate of foreign compounds in biological systems,
J R Fouts, and L A Rogers, and T E Gram
Drug control of steroid metabolism by the hepatic endoplasmic reticulum.
January 1983, Drug metabolism reviews,
J R Fouts, and L A Rogers, and T E Gram
Studies of the stoichiometric relationships between the oxidation of drugs and the oxidation of reduced pyridine nucleotides by liver microsomal enzymes.
August 1971, Chemico-biological interactions,
J R Fouts, and L A Rogers, and T E Gram
Distribution of polycyclic hydrocarbon metabolism-linked enzymes in specialized regions of the endoplasmic reticulum.
June 1979, Biochimica et biophysica acta,
Copied contents to your clipboard!