Biomaterial Database

Effect of 3-amino-1,2,4-triazole on histidine metabolism in algae. 1966

J N Siegel, and A C Gentile

Growth of Chlorella vulgaris and Prototheca zopfii is inhibited by treatment with 3-amino-1,2,4-triazole. Growth of these 2 algae in the presence of amino triazole is accompanied by the accumulation in the culture media of the dephosphorylated histidine precursor, imidazoleglycerol. The addition of histidine to the culture media in the presence of amino triazole restored the normal growth rates of these organisms and reduced the accumulation of imidazoleglycerol. These data suggest that amino triazole inhibits the synthesis of histidine by interfering with the activity of the enzyme, imidazoleglycerol phosphate dehydrase.

UI	MeSH Term	Description	Entries
D006639	Histidine	An essential amino acid that is required for the production of HISTAMINE.	Histidine, L-isomer,L-Histidine,Histidine, L isomer,L-isomer Histidine
D014230	Triazoles	Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.	Triazole
D056890	Eukaryota	One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista.	Eukaryotes,Eucarya,Eukarya,Eukaryotas,Eukaryote
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In