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The incidence of sister chromatid exchange was determined in human leucocyte cultures treated with methylazoxymethanol acetate. In all individuals examined, treated cultures manifested a significantly higher frequency of sister chromatid exchanges than controls. Two concentrations of MAM AC were tested in blood cultures from nine individuals. The concentrations varied from individual to individual since they were determined by means of individual dose-response curves, which involved [3H]-thymidine incorporation in PHA-stimulated short-term lymphocyte cultures versus MAM AC contraction. The lower concentration was less than the TD50 dose. Compared to control cultures, the lower concentration caused a higher incidence of sister chromatid exchange in eight of nine individuals. The cumulative mean value for all control cultures was 5.32 exchanges per cell while that for cultures treated with the higher concentration was 10.73.
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January 1982,
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January 1977,
Annual review of genetics,
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Current protocols in cell biology,
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January 1987,
Boletin de estudios medicos y biologicos,
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January 1981,
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L A Evans, and
M J Kevin, and
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January 2006,
Sub-cellular biochemistry,
L A Evans, and
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November 1998,
International archives of occupational and environmental health,
