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Two rat strains, designated LA and MA, selectively bred for differential impairment of motor activity following an injection of alcohol, were tested in stabilmeters and compared over a range of ethanol doses. As expected, increasing doses of ethanol produced progressively greater activity decrements in both strains; however, the same dose of ethanol induced a more pronounced decrement in the MA strain than in LA strain at all doses. At the highest alcohol dose (2.25 g/kg), the LA animals were twice as active as were the MA strain at the 1.5 g/kg dose. This strain difference in impairment was evident within 3 min postinjection and remained throughout the 30 min test session. The results are discussed in terms of differential neural and behavioral toelrance to ethanol in the two strains.
E D Worsham, and
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May 1977,
Pharmacology, biochemistry, and behavior,
E D Worsham, and
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January 1977,
Drug and alcohol dependence,
E D Worsham, and
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January 1978,
Pharmacology, biochemistry, and behavior,
E D Worsham, and
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August 1982,
Life sciences,
E D Worsham, and
E X Freed
March 2009,
Alcohol (Fayetteville, N.Y.),
E D Worsham, and
E X Freed
April 2004,
Alcoholism, clinical and experimental research,
E D Worsham, and
E X Freed
March 1982,
Behavioral and neural biology,
E D Worsham, and
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January 1977,
Neuroendocrinology,
E D Worsham, and
E X Freed
August 1980,
Behavioral and neural biology,
E D Worsham, and
E X Freed
July 1978,
Psychopharmacology,
