-transparent.png){kind=logo}
The analgesic effects of intracerebroventricular administration of alpha, gamma, and beta-endorphin and their D-Ala2-analogs were examined in the rat using the tail-flick test. Analgesia was produced by all substances. The actions of D-Ala2-alpha and -beta-endorphin were considerably greater than the parent forms, whereas D-Ala2-gamma-endorphin was approximately equivalent to the parent compound. The marked analgesia was dose dependent and prolonged for all analogs. Since these effects were reversed by the opiate antagonist naloxone, it was concluded that opiate receptors mediate the action of these analogs. It is suggested that these analogs may be useful in behavioral tests when a longer duration of action is desirable.
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
April 1984,
Biochemical and biophysical research communications,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
October 1976,
Science (New York, N.Y.),
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
September 1996,
European journal of pharmacology,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
August 1976,
Proceedings of the National Academy of Sciences of the United States of America,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
February 2011,
Peptides,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
January 1985,
Peptides,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
September 1976,
Nature,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
August 1992,
European journal of pharmacology,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
January 2010,
Regional anesthesia and pain medicine,
J M Walker, and
C A Sandman, and
G G Berntson, and
R F McGivern
July 1991,
International journal of peptide and protein research,
