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Highly purified multiple forms of brain cholinesterase were isolated by a new method. Eight forms were identified as acetyl cholinesterases, seven forms--as butyryl cholinesterases, four forms--as mixed acetyl- and butyryl cholinesterases and four forms--as aliesterases. Biosynthesis of multiple forms of brain cholinesterase was monitored by following incorporation of 14C-glycine into the purified fractions. Cats were killed at different periods (3 hrs, 3,6 and 9 days) after intoxication with isopropyl hydroxymethyl fluorophosphate. The restoration of the enzymatic activity after the inhibition did not correspond to the incorporation of the labelled amino acid into the enzyme protein. There was a transcient increase in the incorporation of the label after an increase in acetylcholine concentration.
G K Rusev, and
E L Tomova, and
L S Andreeva
January 1969,
Ukrains'kyi biokhimichnyi zhurnal,
G K Rusev, and
E L Tomova, and
L S Andreeva
January 1977,
Archiv fur experimentelle Veterinarmedizin,
G K Rusev, and
E L Tomova, and
L S Andreeva
January 1977,
Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum,
G K Rusev, and
E L Tomova, and
L S Andreeva
June 1984,
Experimental neurology,
G K Rusev, and
E L Tomova, and
L S Andreeva
January 1971,
Ukrains'kyi biokhimichnyi zhurnal,
G K Rusev, and
E L Tomova, and
L S Andreeva
January 2016,
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti,
G K Rusev, and
E L Tomova, and
L S Andreeva
October 1978,
The Journal of biological chemistry,
G K Rusev, and
E L Tomova, and
L S Andreeva
January 1964,
International review of neurobiology,
G K Rusev, and
E L Tomova, and
L S Andreeva
September 1989,
Biochemistry international,
G K Rusev, and
E L Tomova, and
L S Andreeva
August 1982,
Life sciences,
