Biomaterial Database

[Effect of diketopiperazine on mouse liver regeneration following partial hepatectomy]. 1977

A V Sergeev

Inhibition of serine-hydroxymethyl transferase activity by dimer of cycloserine--diketopiperazin (DP) was studied in vivo in mice liver tissue. DP (2500 mg and 4000 mg per kg of body weight) caused a decrease in the enzyme activity by 14% and 30%, respectively, within 2 hrs after intraperitoneal administration into the animals. Complete reactivation of the enzyme was observed in presence of pyridoxal phosphate added into the experimental samples. DP inhibited the rate of mice liver regeneration after partial hepatectomy, if it was administered separately or in combination with methotrexate within 8 days before and 4 days after the operation. The decreased rate of the tissue regeneration occurred simultaneously with a distinct decrease in the serine-hydroxymethyl transferase activity in vivo. Methotrexate did not affect the liver tissue regeneration after hepatectomy. A method is described for estimation of the serine-hydroxymethyl transferase activity in tissue extracts in presence of partially purified preparation of 5,10-methylene-H4-folate-dehydrogenase.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008115	Liver Regeneration	Repair or renewal of hepatic tissue.	Liver Regenerations,Regeneration, Liver,Regenerations, Liver
D008297	Male		Males
D008727	Methotrexate	An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.	Amethopterin,Methotrexate Hydrate,Methotrexate Sodium,Methotrexate, (D)-Isomer,Methotrexate, (DL)-Isomer,Methotrexate, Dicesium Salt,Methotrexate, Disodium Salt,Methotrexate, Sodium Salt,Mexate,Dicesium Salt Methotrexate,Hydrate, Methotrexate,Sodium, Methotrexate
D008754	Methylenetetrahydrofolate Dehydrogenase (NADP)	An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.	Methylenetetrahydrofolate Dehydrogenase (NADP+),Methylenetetrahydrofolate Dehydrogenase,Dehydrogenase, Methylenetetrahydrofolate
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D003864	Depression, Chemical	The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.	Chemical Depression,Chemical Depressions,Depressions, Chemical
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004789	Enzyme Activation	Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.	Activation, Enzyme,Activations, Enzyme,Enzyme Activations