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Gentamycin concentration in the serum, pericardial fluid, auricle, valve and papillary muscles of 14 patients subjected to cardiac surgery was determined after intramuscular administration of 80 mg of the drug. Fifty to 140 minutes after administration the mean level in the serum was 6.0 mcg/ml, in the pericardial fluid 0.6 mcg/ml, in the auricle 5.8 mcg/g, while after 120 to 240 minutes in the valve 1.2--9.6 mcg/g and in the papillary muscles 2.0--3.6 mcg/g of gentamycin was measured. Consequently, an efficacious gentamycin concentration can be achieved in the cardiac tissues but not in the pericardial fluid which makes gentamycin excellently suited for the prevention and treatment of the infectious complications of heart operations.
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
January 1969,
Deutsche medizinische Wochenschrift (1946),
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
January 1969,
Giornale italiano di chemioterapia,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
December 1976,
Orvosi hetilap,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
January 1979,
Aktuelle Probleme in Chirurgie und Orthopadie,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
January 1988,
Chirurgia maxillofacialis & plastica,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
January 1995,
Annales francaises d'anesthesie et de reanimation,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
July 1998,
Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
January 1988,
Krankenpflege Journal,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
May 1969,
Arzneimittel-Forschung,
J Kiss, and
E Faragó, and
A Gömöry, and
P Homolay, and
I S Kiss
April 1979,
JPMA. The Journal of the Pakistan Medical Association,
