Biomaterial Database

Effects of Serotonin and Histamine on the contractile activity of smooth-muscle strips of sheep complex stomach. 1977

P Vassileva

The effect of histamine and serotonin is studied on strips of the two smooth-muscle layers from the different sections of the complex stomach. Histamine in concentration of 10(-9) to 10(-4) g/ml has no visible effect on preparations from the rumen and reticulum. In strips from the omasum as well as from the proximal and antral regions of the abomasum inhibitory effect is observed mainly with respect to the spontaneous phasic activity of the strips. Serotonin in concentrations of 10(-8) to 10(-4) g/ml has an excitatory effect in almost all preparations studied. Of the forestomach strips it is mostpronouced in rumen strips. The effect consists in an increase of the tone of the preparations. In the proximal region of the abomasum is effect also consists in a rise of the tone, while in strips from the antral region it causes a rise in the amplitude and frequency of the phasic contractions. Serotonin in the concentrations tested has an inhibitory effect only on omasum preparations.

UI	MeSH Term	Description	Entries
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D006632	Histamine	An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.	Ceplene,Histamine Dihydrochloride,Histamine Hydrochloride,Peremin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012701	Serotonin	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.	5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D013279	Stomach, Ruminant	A component of the DIGESTIVE SYSTEM of RUMINANTS which consists of the ABOMASUM; OMASUM; RETICULUM; and RUMEN.	Ruminant Stomach,Ruminant Stomachs,Stomachs, Ruminant