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The passage of noradrenaline from the cerebrovascular circulation into the brain (vessel walls and parenchyma) was studied quantitatively and regionally by a modification of Oldendorf's technique for determination of brain uptake index. Using 14C-ethanol as the highly diffusible internal standard, the index for noradrenaline varied between 2.7 and 4.5% in different regions, confirming the poor penetration of this neurotransmitter. The barrier was impaired transiently as evidenced by Evans blue extravasation, through osmotic opening by internal carotid injection of a hyperosmolar urea solution or mechanical disruption by a short-lasting elevation of the intracarotid hydrostatic pressure. This resulted in a 3-4-fold increase in the passage of noradrenaline from the circulation into the brain.
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
November 1988,
Annals of neurology,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
March 1978,
Ciba Foundation symposium,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
March 1985,
Cancer research,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
September 1971,
Science (New York, N.Y.),
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
July 1978,
Brain research,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
February 1988,
Stroke,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
September 1988,
Journal of neurosurgery,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
May 1980,
The American journal of physiology,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
January 1983,
Neuropathology and applied neurobiology,
J E Hardebo, and
L Edvinsson, and
E T Mackenzie, and
C Owman
October 1979,
Surgical neurology,
