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A critical factor limiting the availability of histocompatible platelet transfusions for alloimmunized, thrombocytopenic patients is the large pool of HLA-typed donors needed to procure platelets perfectly matched for HLA antigens. We have, therefore, investigated the effectiveness of platelets obtained from donors having lesser degrees of histocompatibility. In 421 transfusions administered to 59 alloimmunized patients who were refractory to "random donor" platelets, it was found that platelets mismatched for 1 or 2 "cross-reactive" HLA antigens were in most instances as effective in increasing circulating platelet levels as perfectly matched platelets. A significant number of patients also responded to platelets from donors selectively mismatched for non-cross-reactive HLA antigens. The latter group had a significantly reduced frequency of the antigen HLA-A2 (13%) in comparison to the total patient population (49%). Use of donors whose HLA antigens are serologically cross-reactive with those of alloimmunized patients provides approximately 10 times as many prospective donors as does selection based on matching for HLA and simplifies the procurement of hemostatically effective platelets for such patients.
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
March 1977,
Transplantation proceedings,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
October 1984,
The New Zealand medical journal,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
April 1991,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
January 1984,
Transfusion,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
March 1977,
Transplantation proceedings,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
February 2008,
Transfusion,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
December 1977,
Transplantation proceedings,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
August 1997,
Blood,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
January 1978,
Progress in clinical and biological research,
R J Duquesnoy, and
D J Filip, and
G E Rodey, and
A A Rimm, and
R H Aster
August 1989,
Blood,
