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A new type of cytotoxic immunosuppressive agent: 3-acetyl-5-(4-fluorbenzylidiene)4-hydroxy-2-oxo-2:5-dihydrothiophen. 1966

T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013876 Thiophenes A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur. Thiophene
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
Immunosuppressive activity of 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihydrothiophen (I.C.I. 47,776).
March 1968, Immunology,
T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
Biochemical studies with a new cytotoxic immunosuppressive agent, 3-acetyl-5-(4-fluorobenzylidene)-2,5-dihydro-4-hydroxy-2-oxothiophen (I.C.I. 47776).
March 1967, The Biochemical journal,
T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
The preparation and chemical properties of 3-acyl-5-arylidene-4-hydroxy-2,5-dihydro-2-oxothiophens, a new class of immunosuppressive agent.
January 1968, Journal of the Chemical Society. Perkin transactions 1,
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Piperidinium 3-[(4-hydroxy-5-dimethyl-2-oxo-2H-chromen-3-yl)-phenylmethyl]-5,7-dimethyl-2-oxo-2H-chromen-4-olate.
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T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
[Experimental dermatological testing of the new active agent 4-hydroxy-2-oxo-benzoxathiole].
October 1958, Arzneimittel-Forschung,
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5-Hydroxy-3-indoleacetamidine: a new type of blocking agent against 5-hydroxytryptamine.
November 1961, Nature,
T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
Ethyl 4-acetyl-5-oxo-3-phenyl-hexa-noate.
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T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.
December 1986, Canadian journal of physiology and pharmacology,
T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
(2Z)-3-(5-Hydroxy-4-oxo-4H-chromen-3-yl)acrylonitrile.
April 2005, Acta crystallographica. Section C, Crystal structure communications,
T J Franklin, and B B Newbould, and D M O'Mant, and A I Scott, and G J Stacey, and G E Davies
3-Hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazene.
January 2004, The Journal of organic chemistry,
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