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Dextran-coated charcoal assay with Scatchard plotting was used for the quantitative determination of high-affinity estradiol receptors (ER) in 10 canine mammary tumor cytosols. Mammary tumors diagnosed histopathologically as adenocarcinomas appeared to have a higher incidence of ER than those diagnosed as mixed mammary tumors. These receptors have a high affinity for estradiol with dissociation constants as determined by Scatchard analysis ranging from 1.2 to 2.0 X 10(-11) M. These dissociation constants are similar to those previously reported for the receptor-estradio interaction from target tissues in other species. The specific binding of the receptor for the hormone was diminished in the presence of an antiestrogenic compound. Our data suggest that canine mammary tumors with significant ER levels would respond favorably to antiestrogen therapy. With the demonstration of ER sites in canine mammary adenocarcinomas as presented herein, the potential for chemotherapeutic management appears to be encouraging.
K R Monson, and
J O Malbica, and
Hubben
June 1982,
Cancer research,
K R Monson, and
J O Malbica, and
Hubben
January 2009,
Asian Pacific journal of cancer prevention : APJCP,
K R Monson, and
J O Malbica, and
Hubben
May 1999,
American journal of veterinary research,
K R Monson, and
J O Malbica, and
Hubben
January 2002,
Polish journal of veterinary sciences,
K R Monson, and
J O Malbica, and
Hubben
September 2019,
BMC veterinary research,
K R Monson, and
J O Malbica, and
Hubben
December 1981,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
K R Monson, and
J O Malbica, and
Hubben
January 1975,
Voprosy onkologii,
K R Monson, and
J O Malbica, and
Hubben
January 1987,
Zentralblatt fur Chirurgie,
K R Monson, and
J O Malbica, and
Hubben
December 1984,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
K R Monson, and
J O Malbica, and
Hubben
January 1970,
Pathologia veterinaria,
