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A convenient preparation of reduced and S-sulfonated A and B chains of insulin. 1966

P T Varandani

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D002845 Chromatography Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts. Chromatographies
D004586 Electrophoresis An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current. Electrophoreses
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D013447 Sulfites Inorganic salts of sulfurous acid. Sulfite,Sulfites, Inorganic,Inorganic Sulfites
D013451 Sulfonic Acids Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical. Sulfonic Acid,Acid, Sulfonic,Acids, Sulfonic

Related Publications

P T Varandani
Studies on the synthesis of insulin from natural and synthetic A and B chains. I. Splitting of insulin and isolation of the S-sulfonated derivatives of the A and B chains.
September 1967, Biochemistry,
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Isolation of the B and C chains from S-sulfonated alpha-chymotrypsin.
October 1966, Biochimica et biophysica acta,
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[Reactions of reduced A- and B-chains with insulin].
June 1968, Diabetologia,
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[Preparation of N-acetyl S-sulfonate chains of beef insulin].
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Human proinsulin, VIII: studies on the S-tritylation of reduced proinsulin, insulin A and B chains and their detritylation.
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A convenient preparation of S-adenosylhomocysteine and related compounds.
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H spin system identifications of S-sulfonated insulin B chain with 2D-NMR.
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Biosynthesis of insulin chains A and B.
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Preparation, sedimentation, and deuterium exchange studies of the oxidized A and B chains of insulin.
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Insulin peptides. XXI. A synthesis of the B chain of sheep (bovine, porcine) insulin and its isolation as the S-sulfonated derivative.
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