-transparent.png){kind=logo}
The present study was designed to test the hypothesis that the vasoconstrictive effects of alpha-adrenergic receptors are responsible, at least in part, for the lack of a maximal vasodilatation of coronary arteries during hemorrhagic shock. Open-chested, anesthetized, mongrel dogs were bled so as to reach an arterial pressure level of 44 mm Hg, and were monitored using an electromagnetic, non-cannulating flowmeter. During shock, two intracoronary injections were made, one of saline, the other of phenoxybenzamine (Dibenzyline). Control dogs had 2 injections of saline. Following phenoxybenzamine, coronary blood flow increased by 32%. These results indicate that although coronary blood flow may be mainly under local control, the sympathetic nervous system limits maximal coronary vasodilatation during hemorrhagic shock by virtue of activated alpha-adrenergic receptors.
F Birinyi, and
D B Hackel, and
E Mikat
May 1977,
The American journal of physiology,
F Birinyi, and
D B Hackel, and
E Mikat
August 1987,
The American journal of physiology,
F Birinyi, and
D B Hackel, and
E Mikat
August 1966,
The American journal of physiology,
F Birinyi, and
D B Hackel, and
E Mikat
July 1982,
The American journal of physiology,
F Birinyi, and
D B Hackel, and
E Mikat
December 1985,
The American journal of physiology,
F Birinyi, and
D B Hackel, and
E Mikat
November 1987,
Circulation research,
F Birinyi, and
D B Hackel, and
E Mikat
December 1980,
Archivos de biologia y medicina experimentales,
F Birinyi, and
D B Hackel, and
E Mikat
January 1968,
Cardiovascular research,
F Birinyi, and
D B Hackel, and
E Mikat
January 1968,
Tip Fakultesi mecmuasi,
F Birinyi, and
D B Hackel, and
E Mikat
April 2004,
Experimental biology and medicine (Maywood, N.J.),
