-transparent.png){kind=logo}
During treatment of active pulmonary tuberculosis with isoniazid, rifampicin and ethambutol in 15 patients transaminase activity increased in seven to levels of 60-340 U/l (group I). In the other eight the laboratory values remained within normal limits (group II). Rifampicin levels in group I were significantly raised at 2 and 5 hours after administration of 10 mg/kg body weight on proven fasting. There was no significant difference between the two groups for isoniazid. Estimated half-life of rifampicin was significantly longer in the first than the second group. If there is evidence of chronic liver disease (by history or by chemical tests) the rifampicin dose should be decreased to less than 10 mg/kg body weight.
P Knop, and
U Kindler, and
A Austerhoff
November 1974,
Praxis der Pneumologie,
P Knop, and
U Kindler, and
A Austerhoff
December 1981,
Anales espanoles de pediatria,
P Knop, and
U Kindler, and
A Austerhoff
June 1977,
Revista medica de Chile,
P Knop, and
U Kindler, and
A Austerhoff
June 1982,
Pathologie-biologie,
P Knop, and
U Kindler, and
A Austerhoff
May 1980,
Kekkaku : [Tuberculosis],
P Knop, and
U Kindler, and
A Austerhoff
October 1978,
Biochemical medicine,
P Knop, and
U Kindler, and
A Austerhoff
July 1979,
The Journal of antimicrobial chemotherapy,
P Knop, and
U Kindler, and
A Austerhoff
April 1978,
La Nouvelle presse medicale,
P Knop, and
U Kindler, and
A Austerhoff
May 1984,
Annals of clinical biochemistry,
P Knop, and
U Kindler, and
A Austerhoff
April 1977,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
