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The effect of gonadotropin pretreatment of hypophysectomized male rats on LH stimulated serum testosterone concentrations was studied. A 5 day pretreatment period began 2 days after hypophysectomy at 21 or 24 days of age. On the day following the pretreatment period the animals received an intraperitoneal injection of saline or LH 60 min before blood collection. Animals pretreated with NIH-FSH-B1, or with doses of LH approximating the amount present in the NIH-FSH, had increased testosterone concentrations after LH stimulation compared to similarly stimulated saline pretreated animals. Pretreatment with more highly purified FSH Ex 199C at a lower dose than the minimum effective dose of NIH-FSH was also effective. There was no synergistic or additive effect when FSH Ex 199C and LH pretreatments were combined. FSH Ex 199C is more potent and contains appreciably less LH contamination than NIH-FSH-B1. The results obtained using FSH Ex 199C indicate that FSH, independent of LH contamination, can increase testes response to LH stimulation.
L K Selin, and
W H Moger
February 1981,
Archives of andrology,
L K Selin, and
W H Moger
August 1978,
Endocrinologia japonica,
L K Selin, and
W H Moger
July 1987,
Brain research bulletin,
L K Selin, and
W H Moger
September 1974,
Endocrinology,
L K Selin, and
W H Moger
January 1976,
Endocrinology,
L K Selin, and
W H Moger
March 1975,
Klinische Wochenschrift,
L K Selin, and
W H Moger
August 1979,
Biology of reproduction,
L K Selin, and
W H Moger
June 1972,
Endocrinology,
L K Selin, and
W H Moger
September 1981,
The American journal of physiology,
L K Selin, and
W H Moger
January 1976,
Endokrinologie,
