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The effects of acute introduction and withdrawal of 2 new beta-adrenergic blockers, acebutolol and metoprolol, on sleep in normal subjects were investigated. Both the subjective effects of the drug and EEG sleep variables were determined during a baseline period with placebo and in relation to the drug. The results showed that neither drug had a significant effect on sleep pattern in normal subjects. However, a transient effect on certain sleep parameters was seen on the first night of drug administration, with complete return to baseline, on the following night without any evidence of rebound. Possible mechanisms to explain the central actions of beta-adrenergic blockers are briefly discussed.
K Kayed, and
O B Godtlibsen
January 1982,
Biopharmaceutics & drug disposition,
K Kayed, and
O B Godtlibsen
January 1986,
European journal of clinical pharmacology,
K Kayed, and
O B Godtlibsen
January 1979,
Acta pharmaceutica Suecica,
K Kayed, and
O B Godtlibsen
October 1977,
British journal of clinical pharmacology,
K Kayed, and
O B Godtlibsen
April 1994,
British journal of clinical pharmacology,
K Kayed, and
O B Godtlibsen
December 1997,
Journal of cardiovascular pharmacology,
K Kayed, and
O B Godtlibsen
January 1985,
Adverse drug reactions and acute poisoning reviews,
K Kayed, and
O B Godtlibsen
January 1978,
Clinical and experimental pharmacology & physiology,
K Kayed, and
O B Godtlibsen
January 1983,
Clinical pharmacology and therapeutics,
K Kayed, and
O B Godtlibsen
January 1984,
British journal of clinical pharmacology,
