Hepatic injury and drug metabolism in patients with alpha-methyldopa-induced liver damage. 1977

E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008750 Methyldopa An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. Methyldopate,alpha-Methyldopa,Aldomet,Alphamethyldopa,Apo-Methyldopa,Dopamet,Dopegit,Dopegyt,Dopergit,Hydopa,Meldopa,Nu-Medopa,Sembrina,alpha-Methyl-L-Dopa,Apo Methyldopa,Nu Medopa,alpha Methyl L Dopa,alpha Methyldopa
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003577 Cytochrome P-450 Enzyme System A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. Cytochrome P-450,Cytochrome P-450 Enzyme,Cytochrome P-450-Dependent Monooxygenase,P-450 Enzyme,P450 Enzyme,CYP450 Family,CYP450 Superfamily,Cytochrome P-450 Enzymes,Cytochrome P-450 Families,Cytochrome P-450 Monooxygenase,Cytochrome P-450 Oxygenase,Cytochrome P-450 Superfamily,Cytochrome P450,Cytochrome P450 Superfamily,Cytochrome p450 Families,P-450 Enzymes,P450 Enzymes,Cytochrome P 450,Cytochrome P 450 Dependent Monooxygenase,Cytochrome P 450 Enzyme,Cytochrome P 450 Enzyme System,Cytochrome P 450 Enzymes,Cytochrome P 450 Families,Cytochrome P 450 Monooxygenase,Cytochrome P 450 Oxygenase,Cytochrome P 450 Superfamily,Enzyme, Cytochrome P-450,Enzyme, P-450,Enzyme, P450,Enzymes, Cytochrome P-450,Enzymes, P-450,Enzymes, P450,Monooxygenase, Cytochrome P-450,Monooxygenase, Cytochrome P-450-Dependent,P 450 Enzyme,P 450 Enzymes,P-450 Enzyme, Cytochrome,P-450 Enzymes, Cytochrome,Superfamily, CYP450,Superfamily, Cytochrome P-450,Superfamily, Cytochrome P450
D004364 Pharmaceutical Preparations Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form. Drug,Drugs,Pharmaceutical,Pharmaceutical Preparation,Pharmaceutical Product,Pharmaceutic Preparations,Pharmaceutical Products,Pharmaceuticals,Preparations, Pharmaceutical,Preparation, Pharmaceutical,Preparations, Pharmaceutic,Product, Pharmaceutical,Products, Pharmaceutical
D005260 Female Females
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
January 1981, Scandinavian journal of gastroenterology,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
January 1981, Scandinavian journal of gastroenterology,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
October 1969, Circulation,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
January 1978, Acta medica Scandinavica,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
February 2017, Clinics in liver disease,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
March 2012, Expert opinion on drug metabolism & toxicology,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
January 1979, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
August 1980, British journal of clinical pharmacology,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
August 1974, British medical journal,
E A Sotaniemi, and O T Hokkanen, and J T Ahokas, and R O Pelkonen, and J Ahlqvist
April 1974, Gut,
Copied contents to your clipboard!