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The effect of induced hypercalcemia on serum gastrin concentrations, measured by radioimmunoassay, and gastric acid secretion was studied in 20 healthy subjects, 8 patients after antrectomy and gastroduodenostomy (Billroth I), 12 patients after antrectomy and gastrojejunostomy (Billroth II) and in 9 patients after total gastrectomy and esophagojejunostomy. In normal man calcium stimulates gastric secretion and gastrin release. After antrectomy gastric secretion is still stimulated by calcium without changing serum gastrin levels. After total gastrectomy basal serum gastrin concentration is further reduced; calcium does not liberate gastrin. These results show that calcium-induced gastric secretion is caused by direct action at the parietal cell level besides the gastrin release from the antrum. In man, extra antral gastrin cannot be released by induced hypercalcemia.
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
May 1974,
Klinische Wochenschrift,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
May 1974,
Wiener klinische Wochenschrift,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
January 1979,
Scandinavian journal of gastroenterology. Supplement,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
December 1975,
Surgery, gynecology & obstetrics,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
June 1979,
Zeitschrift fur Gastroenterologie,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
June 1975,
Surgery,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
December 1986,
Hepato-gastroenterology,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
January 1982,
La Ricerca in clinica e in laboratorio,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
October 1977,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
A Schafmayer, and
H W Börger, and
T Stuhler, and
R Siewert, and
H D Becker
December 1977,
The American journal of gastroenterology,
