Mirex, the organochlorine compound used for control of the imported fire ant (Solenopsis invicta Buren), was applied aerially under supervision of the South Carolina Plant Pest Regulatory Service in October 1975 to a game management area in Hampton County, S.C. Influenced by recent reports indicating that low levels of mirex were toxic to certain nontarget organisms in laboratory studies, authors initiated a program for monitoring mirex residues in bobwhite quail (Colinus virginianus). Pretreatment residues were recorded on a dry-weight basis in bobwhite quail breast and adipose tissue; conversion factors for determining wet-weight concentrations are approximately as follows: fat, 0.77; and breast, 0.29. Residues ranged from 0.000-0.178 ppm and 0.247-2.763 ppm, respectively. Mirex residues in quail adipose tissue showed up to five-fold increase within the first month after treatment and declined thereafter. A residue peak was noticed the spring following mirex treatment, corresponding with insect emergence. Mirex residues in quail collected in summer 1976 following a fall bait application showed slightly higher residue levels than had birds taken in summer 1975; however, little, if any, human food chain contamination would result in the consumption of birds with residue levels found in this study.