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To evaluate the role of reduced erythropoietin (Ep) production in the pathogenesis of dialysis anaemia, measurements of serum erythropoietin (SEp) concentration by means of a highly sensitive in vitro bioassay were performed in 88 non-nephrectomised non-transfused regular haemodialysis patients. In 50 patients (group 1) SEp levels were lower than 120 mU/ml. In the remaining 38 patients (group 2) SEp concentrations ranged from 120-369 mU/ml. Group 1 showed a highly significant positive correlation between SEp concentration and haematocrit as did 13 anephric patients investigated for comparison. In contrast, group 2 displayed a highly significant negative correlation between SEp concentration and haematocrit. The results demonstrate the existence of two distinctive groups of similar size in regular haemodialysis patients: those with an absolute (group 1) and those with a relative deficiency of Ep (group 2). In the case of the latter, lack of Ep is probably a secondary factor in the pathogenesis of anaemia, whereas uraemic toxicity and blood loss may play a primary role.
H W Radtke, and
P M Erbes, and
W Fassbinder, and
K M Koch
October 1979,
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H W Radtke, and
P M Erbes, and
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K M Koch
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H W Radtke, and
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K M Koch
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H W Radtke, and
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H W Radtke, and
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H W Radtke, and
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H W Radtke, and
P M Erbes, and
W Fassbinder, and
K M Koch
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H W Radtke, and
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K M Koch
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H W Radtke, and
P M Erbes, and
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H W Radtke, and
P M Erbes, and
W Fassbinder, and
K M Koch
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