A double-glind comparative trial of naproxen and indomethacin in sports injuries. 1977

J G Williams, and C Engler

Fifty patients suffering from sports injuries were included in a double-blind trial comparing the efficacy and side-effects of naproxen and indomethacin. The patients' daily record cards showed that the number of patients whose paine cleared in less than seven days was statistically significantly greater in the naproxen grout (P = 0.03). Overall change at the seven-day follow-up visit, changes in the degree of pain, swelling and limitation of movement, as well as the number of patients ready for full activity at seven days were also greater in the naproxen group. However, the differences between the two groups of treatment did not reach statistical significance. The number of side-effects was equal in both treatment groups. One patient on indomethacin had to be withdrawn from the trial after two days' treatment, because of severe gastric pains.

UI MeSH Term Description Entries
D007213 Indomethacin A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D008297 Male Males
D009288 Naproxen An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. Aleve,Anaprox,Methoxypropiocin,Naprosin,Naprosyn,Naproxen Sodium,Proxen,Sodium Naproxenate,Synflex,Naproxenate, Sodium,Sodium, Naproxen
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001265 Athletic Injuries Injuries incurred during participation in competitive or non-competitive sports. Sports Injuries,Injuries, Athletic,Injuries, Sports,Athletic Injury,Injury, Athletic,Injury, Sports,Sports Injury

Related Publications

J G Williams, and C Engler
June 1982, British journal of sports medicine,
J G Williams, and C Engler
November 1971, Arzneimittel-Forschung,
J G Williams, and C Engler
May 1988, The American journal of medicine,
J G Williams, and C Engler
February 1974, The Medical journal of Australia,
J G Williams, and C Engler
January 1974, Scandinavian journal of rheumatology,
J G Williams, and C Engler
January 1973, Scandinavian journal of rheumatology. Supplement,
J G Williams, and C Engler
April 1975, Journal of clinical pharmacology,
Copied contents to your clipboard!