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Twenty eight patients with hereditary methemoglobinemia have been found and examined. Using the techniques of analytic isoelectrofucossing in polyacrylamide gel and the preparative isoelectrofocussing on a column in sucrose gradient we have managed to disclose an abnormal fraction in hemolysate of the above mentioned patients. It has been proved that the obtained fraction contains hemoglobin valent hybrids, possesses high affinity to oxygen and low cooperativity. Due to the presence of valency hybrids about one-half of the quantity of oxy-Hb fails to participate in the normal function of oxygen delivery, which evidently is the molecular cause of disturbance of oxygen delivery in patients with hereditary enzymopenic methemoglobinemia. This also explains a high degree of cyanosis in them.
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
May 1977,
Klinicheskaia meditsina,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
December 1982,
Haematologia,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
January 1997,
Klinicheskaia meditsina,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
January 1986,
Blood cells,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
November 2000,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
January 1973,
Medicinski pregled,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
January 1994,
Methods in enzymology,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
January 1977,
Doklady Akademii nauk SSSR,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
November 1981,
Problemy gematologii i perelivaniia krovi,
A P Andreyeva, and
M G Dmitriyeva, and
A A Levina, and
L M Tsibulskaya, and
Y G Kazanetz, and
I I Ilyinskaya, and
I V Derviz, and
Y N Tokarev
May 1977,
Archives of biochemistry and biophysics,
