BIOMAT Database Logo BIOMAT Database Logo

Insulin deficiency and cell proliferation in oral mucosal epithelium of the rat. 1977

A I Hamilton, and H J Blackwood

The duration of the cell cycle (C) and its component phases (G1, S, G2 and M), the rate of cell proliferation, and the renewal time, in the epithelium of the hard palate of alloxan-diabetic rats have been determined and compared with values of the same variables obtained previously from normal rats. The data have been derived by means of autoradiography with [3H]thymidine and the method of labelled mitoses. The values for the normal animals were found to be: G1 = 38 hours, S = 8 hours, G2 = 1 hour, M = 1 hour, C = 48 hours (or 2.1%/hour); and for the diabetic animals were: G1 = 42.5 hours, S = 8.5 hours, G2 = 1 hour, M = 1 hour, C = 53 hours (or 1.9%/hour); and for the renewal time for the epithelium, 6.5-8 days. In the diabetic animals the duration of S was increased by 6%, G1 by 12% and the cell cycle by about 10%. The reduced rate of cell proliferation that is associated with insulin deficiency may contribute to the slower rate of wound healing in subjects with diabetes mellitus.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297 Male Males
D008938 Mitosis A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. M Phase, Mitotic,Mitotic M Phase,M Phases, Mitotic,Mitoses,Mitotic M Phases,Phase, Mitotic M,Phases, Mitotic M
D009061 Mouth Mucosa Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations. Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D010159 Palate The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT). Incisive Papilla,Incisive Papillas,Palates,Papilla, Incisive,Papillas, Incisive
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D004848 Epithelium The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body. Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

A I Hamilton, and H J Blackwood
A cybernetic model of cell renewal in oral mucosal epithelium.
January 1972, Gegenbaurs morphologisches Jahrbuch,
A I Hamilton, and H J Blackwood
[Cell proliferation and differentiation in the tracheal epithelium of the rat].
May 1968, Experimental cell research,
A I Hamilton, and H J Blackwood
Effect of ascorbic acid deficiency on the permeability and collagen biosynthesis of oral mucosal epithelium.
September 1975, Annals of the New York Academy of Sciences,
A I Hamilton, and H J Blackwood
Cell proliferation in the gastric epithelium of the ulcer rat.
December 2005, Scandinavian journal of gastroenterology,
A I Hamilton, and H J Blackwood
[Cytology of the oral mucosal epithelium in leukemia].
June 1977, Czasopismo stomatologiczne,
A I Hamilton, and H J Blackwood
Iron deficiency depresses cell proliferation in hamster cheek pouch epithelium.
July 1987, Cell and tissue kinetics,
A I Hamilton, and H J Blackwood
Indomethacin inhibits cell proliferation in the oxyntic epithelium of the rat.
January 1993, Prostaglandins,
A I Hamilton, and H J Blackwood
Adrenergic inhibition of cell proliferation in the buccal epithelium of rat.
October 1976, Virchows Archiv. B, Cell pathology,
A I Hamilton, and H J Blackwood
The effect of vitamin A on the proliferation of oral epithelium in the rat.
April 1994, Australian dental journal,
A I Hamilton, and H J Blackwood
Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat.
August 2008, Journal of pediatric gastroenterology and nutrition,
Copied contents to your clipboard!