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The preparation of large quantities of a stable, stroma-free hemoglobin solution without coagulant activity is described. Following infusion of this solution into phlebotomized dogs, there is no methemoglobin formation, no adverse effects on vital signs, and no demonstrable activation of blood coagulation. The hemoglobin maintains its oxygen-carrying capacity and liberates oxygen into tissues. Acute and chronic effects on renal function following infusion of this preparation were also studied and no effect on clearance of urea, creatinine, or P.A.H. could be demonstrated. There was no change in urinary output and histological sections revealed no lesions attributable to hemoglobin toxicity. It is concluded that a stroma-free hemoglobin solution may have use as a plasma expander.
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
May 1975,
Federation proceedings,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
April 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
December 1985,
Surgery, gynecology & obstetrics,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
January 1974,
Journal of surgical oncology,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
January 1977,
Surgical forum,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
January 1974,
Journal of surgical oncology,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
October 1981,
The Journal of thoracic and cardiovascular surgery,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
January 1975,
Surgical forum,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
January 1972,
Surgical forum,
S F Rabiner, and
J R Helbert, and
H Lopas, and
L H Friedman
November 1983,
Surgery, gynecology & obstetrics,
