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The high circulating concentrations of immunoassayable parathyroid hormone observed in chronic renal failure are due to a number of factors. These include altered metabolism of the hormone and also end-organ unresponsiveness which may, indirectly, cause increased secretion of parathyroid hormone. The response of the overactive parathyroid glands to changes in plasma calcium and magnesium is variable and caution is needed in evaluating the suppressibility of parathyroid hormone secretion in acute studies. 1alpha-Hydroxylated derivatives of vitamin D can effectively suppress parathyroid gland overactivity. This effect may not necessarily be medicated through hypercalcaemia and vitamin D metabolites may act directly on the parathyroid glands.
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
September 1970,
Lancet (London, England),
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
January 1983,
Scandinavian journal of urology and nephrology. Supplementum,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
January 1981,
Annals of clinical and laboratory science,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
January 1972,
Acta medica Iugoslavica,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
August 1983,
Southern medical journal,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
May 1973,
Urological research,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
December 1982,
European journal of pediatrics,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
April 1995,
Nihon rinsho. Japanese journal of clinical medicine,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
July 1970,
The Quarterly journal of medicine,
S E Papapoulos, and
A M Brownjohn, and
B J Junor, and
F P Marsh, and
F J Goodwin, and
W Hately, and
I G Lewin, and
S Tomlinson, and
G N Hendy, and
J L O'Riordan
August 1998,
Nephron,
