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Leucopenia rendered rats unresponsive to various inflammatory stimuli. The intensity of the inflammatory response in such animals was restored by i.v. administration of suspensions of lymphocytes, but not of granulocytes. This restorative effect was blocked by both steroidal and non-steroidal anti-inflammatory drugs. Utilizing carrageenin to induce inflammatory responses in the rat's paw, the effect of these drugs on lymphocytes was observed in two circumstances. First, following incubation of the cells with the drugs in concentrations not exceeding the peak plasma levels estimated for these substances in man or laboratory animals; the effect of the drugs seemed selective, since anti-histamine and anti-serotonin agents, as well as amethopterin, were devoid of action. Second, when lymphocytes were collected from rats previously treated with the various anti-inflammatory agents, injected 6-hourly during periods of 18 and 36 h, respectively, for steroidal and non-steroidal anti-inflammatory substances. The total amounts given were lower than those required to produce consistent anti-inflammatory effects in normal animals, when the drug was given as a single dose before injection of the irritant. It is concluded that the pro-inflammatory function of lymphocytes in non-immune inflammation can be blocked by steroidal and non-steroidal anti-inflammatory agents.
J G Leme, and
G H Bechara, and
L S Sudo
September 1996,
Pathologie-biologie,
J G Leme, and
G H Bechara, and
L S Sudo
January 1979,
Reumatizam,
J G Leme, and
G H Bechara, and
L S Sudo
January 1999,
Srpski arhiv za celokupno lekarstvo,
J G Leme, and
G H Bechara, and
L S Sudo
April 1995,
La Revue du praticien,
J G Leme, and
G H Bechara, and
L S Sudo
March 2003,
La Revue du praticien,
J G Leme, and
G H Bechara, and
L S Sudo
June 1987,
Soins; la revue de reference infirmiere,
J G Leme, and
G H Bechara, and
L S Sudo
January 1978,
Schweizerische Zeitschrift fur Sportmedizin,
J G Leme, and
G H Bechara, and
L S Sudo
May 1991,
Revue du rhumatisme et des maladies osteo-articulaires,
J G Leme, and
G H Bechara, and
L S Sudo
August 1987,
Klinika oczna,
J G Leme, and
G H Bechara, and
L S Sudo
September 2002,
Revue medicale de Liege,
