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Rg and Ch typing was performed, by serum inhibition, on 145 families that had been typed for HLA/C4/BF/C2 with a view to assessing partial inhibition (p.i.) of anti-Rg/Ch and its haplotype associations. Rg p.i. was found predominantly with the C4A*3A*2,B*QO homoduplicated C4 haplotype and BFF. The original type of Ch p.i. (Nordhagen et al., 1980) was closely associated with the allotype C4B 2, which also occasionally exhibited complete inhibition (c.i.), but this Ch p.i. was also found with the C4A*1,B*QO haplotype (Rittner et al., 1984a). The second type of Ch p.i. (Giles, 1984) was closely associated with the C4B 1 allotype most frequently in the haplotype C4A*6,B*1 but also with C4A*3,B*1. Both types of Ch p.i. are usually found with BF S. The present data indicate that the determinants of Rg and Ch are not directly related to any particular C4 allotype or extended haplotype. Further examples of C4A 1 with Ch and C4B 5 without Ch determinants have been detected and theoretical considerations are discussed as to how they might have arisen from unequal crossovers in homologous regions that result in hybrid protein molecules.
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
January 1985,
Vox sanguinis,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
January 1985,
Vox sanguinis,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
November 1984,
Journal of immunology (Baltimore, Md. : 1950),
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
January 1988,
Journal of immunogenetics,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
January 1984,
Vox sanguinis,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
December 1981,
Journal of immunogenetics,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
March 1993,
Nihon Jinzo Gakkai shi,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
January 1996,
Immunohematology,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
September 1998,
Tissue antigens,
C M Giles, and
J R Batchelor, and
I A Dodi, and
A H Fielder, and
C Rittner, and
G Mauff, and
K Bender, and
C Levene, and
G M Schreuder, and
L J Wells
January 1987,
Immunogenetics,
