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To explain the variation in the percentage of mouse erythrocyte rosette-forming cells (MERFC) during culture of Epstein-Barr virus (EBV)-induced B-cell lines, we provide evidence that (i) there is an altered expression of mouse red blood cell (MRBC) receptors on cell line cells during the mitotic cycle, and (ii) putative receptor-negative cells are capable of de novo synthesis of the receptor, and passively adsorbing receptor shed from receptor-positive cells.
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