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The effects of 10(-4)M indomethacin on tissue prostaglandin E2 levels, cyclic AMP concentrations, and acid secretion as measured by the intraglandular accumulation of [14C]aminopyrine were evaluated in unstimulated and histamine-stimulated isolated rabbit fundic glands. Indomethacin (10(-4)M) reduced endogenous prostaglandin E2 content by 52% in unstimulated glands. Indomethacin tripled histamine (10(-6)-10(-4)M-stimulated aminopyrine uptake while not affecting aminopyrine accumulation in unstimulated glands. Indomethacin did not affect cyclic AMP levels in either the unstimulated or stimulated condition.
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