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Six normal subjects were given clonidine infusions after 0, 1 and 3 weeks of treatment with desipramine (2 mg/kgm) and at 1 and 3 weeks after withdrawal from desipramine. The sedative and hypotensive effects of clonidine were inhibited after one and three weeks of desipramine treatment, and returned to normal after stopping treatment without any rebound increase. Such a time-course can be explained in terms of the acute effects of the drug, no adaptive changes at receptors need be invoked. By contrast, the growth hormone response to clonidine tended to be increased after one week of desipramine, reduced after three weeks of treatment, and further reduced after discontinuation. Such a time-course is consistent with an adaptive down regulation at alpha 2 adrenoceptors in response to their acute stimulation, due to noradrenaline re-uptake blockade.
T H Corn, and
C Thompson, and
S A Checkley
April 1992,
Biological psychiatry,
T H Corn, and
C Thompson, and
S A Checkley
October 1982,
The British journal of psychiatry : the journal of mental science,
T H Corn, and
C Thompson, and
S A Checkley
February 1991,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
T H Corn, and
C Thompson, and
S A Checkley
October 1988,
The Journal of pharmacology and experimental therapeutics,
T H Corn, and
C Thompson, and
S A Checkley
September 1950,
The Annals of otology, rhinology, and laryngology,
T H Corn, and
C Thompson, and
S A Checkley
January 1981,
Journal of neural transmission,
T H Corn, and
C Thompson, and
S A Checkley
January 1986,
Archives of general psychiatry,
T H Corn, and
C Thompson, and
S A Checkley
February 1965,
The American journal of cardiology,
T H Corn, and
C Thompson, and
S A Checkley
January 1958,
American review of tuberculosis,
T H Corn, and
C Thompson, and
S A Checkley
January 1993,
European journal of clinical pharmacology,
