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An obvious relationship between changes in ACTH, gonadotrophin, prolactin and cortisol secretion was discovered on the basis of studying the basal ACTH, cortisol, LH, FSH and prolactin levels, as well as from correlative examination of the data obtained in 30 females with Icenko-Cushing's diseases. It is suggested that combined ACTH, gonadotrophin and prolactin secretion occurs in the active stage of the disease, whereas cortisol inhibits gonadotrophin production. A degree of gonadotrophic insufficiency is dependent on the ratio of excessive ACTH-cortisol secretion.
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