-transparent.png){kind=logo}
5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate) is a potent and selective ligand for benzodiazepine (BZ) receptors. Biochemical investigations indicate that ZK 91296 may be a partial agonist at BZ receptors. Such partial agonism may explain to some extent why ZK 91296 needs higher BZ receptor occupancy than diazepam for the same effect against chemical convulsants and for behavioural effects. The lack of sedative effects, and the very potent inhibition of reflex epilepsy, spontaneous epilepsy and DMCM-induced seizures suggest, furthermore, that ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
June 1983,
European journal of pharmacology,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
June 1984,
European journal of pharmacology,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
January 1983,
Advances in biochemical psychopharmacology,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
May 1987,
Neuropharmacology,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
September 1992,
The Journal of pharmacology and experimental therapeutics,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
January 1986,
Journal of neural transmission,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
May 1987,
Journal of neurochemistry,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
June 1991,
Behavioural pharmacology,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
April 1985,
European journal of pharmacology,
E N Petersen, and
L H Jensen, and
T Honoré, and
C Braestrup, and
W Kehr, and
D N Stephens, and
H Wachtel, and
D Seidelman, and
R Schmiechen
January 1991,
Psychopharmacology bulletin,
