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Characteristics of the (3H) Rauwolscine binding were studied in homogenates of rat cerebral cortex, particularly in presence of NaCl. We had shown that (3H) Rauwolscine specifically bind the alpha 2-adrenoceptors. The Scatchard plot analysis had demonstrated 2 sites: a high affinity site (B 41,06 +/- 5,21 KD = 1,31 +/- 0,16) and a low affinity site (B = 203,41 +/- 13,37 KD = 11,62 +/- 0,55 nM). Incubation of cerebral cortex homogenates with NaCl 150 mM induced an increase (53,97 p less than 0.001) of the high affinity site density. These results indicate that (3H) Rauwolscine is a useful alpha 2-adrenoceptor ligand to study in animal models various central nervous system abnormalities or diseases induced by ion disorders.
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Digestive diseases and sciences,
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January 1985,
Hypertension (Dallas, Tex. : 1979),
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Science (New York, N.Y.),
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September 1991,
Molecular pharmacology,
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November 1984,
Arerugi = [Allergy],
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September 1972,
Neuropharmacology,
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Biochemical and biophysical research communications,
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Endocrinology,
