Biomaterial Database

Different importance of primary lymphoid organs for Rous sarcoma regression in inbred lines of chickens. 1984

J Plachý, and V Benda, and I Karakoz, and Z Spaténková

Resistance to progressive growth of tumours induced by Rous sarcoma virus is controlled mainly by genes linked to the B complex (the major histocompatibility complex) of the chicken. The effect of thymectomy and bursectomy on this resistance was studied in chickens from highly inbred lines and their F1 hybrids which differ by the genotype at the B complex and by the degree of genetically controlled resistance or susceptibility. The results show that thymectomy has considerable effect on growth of RSV-induced tumours in the CB line genetically resistant to progressive Rous sarcoma growth and little effect in (CB X IC)F1 (also genetically resistant) and (CC X IC)F1 (intermediate responders to RSV) hybrid chickens. Bursectomy influences the expression of this resistance to a lesser extent than thymectomy. The results indicate that resistance to the development of progressively growing tumours is of a complex nature, the individual components of the immune system are more or less important for its expression in different experimental models. Thus genetically defined animal models have become useful tools for studying carcinogenesis.

UI	MeSH Term	Description	Entries
D007109	Immunity	Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.	Immune Process,Immune Response,Immune Processes,Immune Responses,Process, Immune,Response, Immune
D008221	Lymphoid Tissue	Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.	Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D008285	Major Histocompatibility Complex	The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.	Histocompatibility Complex,Complex, Histocompatibility,Complex, Major Histocompatibility,Complices, Histocompatibility,Complices, Major Histocompatibility,Histocompatibility Complex, Major,Histocompatibility Complices,Histocompatibility Complices, Major,Major Histocompatibility Complices
D002060	Bursa of Fabricius	An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.	Fabricius Bursa
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005838	Genotype	The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.	Genogroup,Genogroups,Genotypes
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001357	Sarcoma, Avian	Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.	Avian Sarcoma,Rous Sarcoma,Sarcoma, Rous,Avian Sarcomas,Sarcomas, Avian
D013950	Thymus Gland	A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.	Thymus,Gland, Thymus,Glands, Thymus,Thymus Glands