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The immunopotentiating effect of the intradermal administration of a course of four doses (0.25 ml) of a standard suspension of killed C. parvum (2 mg/ml) was studied in a group of 10 asymptomatic chronic hepatitis B surface antigen (HBsAg) carriers, as well as in 11 persons with antibodies to HBsAg (anti-HBs) and six without HBsAg or anti-HBs. HBsAg, anti-HBs, and leukocyte migration inhibition (LMI) studies were performed in pre- and post-inoculation blood samples. C. parvum produced a substantial increase of anti-HBs titre in persons with preexisting anti-HBs. However, anti-HBs responses were not induced in carriers. HBsAg was not eliminated and its titre remained practically unchanged in carriers. These results support the hypothesis that in carriers the specific defect in the immune response to HBsAg possibly exists at the B cell level.
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
January 1977,
Developments in biological standardization,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
March 1976,
Clinical immunology and immunopathology,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
February 1978,
Clinical immunology and immunopathology,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
February 2013,
Research in veterinary science,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
January 1977,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
July 1975,
Journal of the National Cancer Institute,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
April 1976,
Cancer research,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
October 1975,
Gastroenterology,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
January 1977,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
G Papaevangelou, and
L Sparros, and
C Vissoulis, and
A Kyriakidou, and
G Giokas, and
J Hadzimanolis, and
D Trichopoulos
October 1977,
Infection and immunity,
