-transparent.png){kind=logo}
To investigate the effect of thyroid hormones on erythrocyte cation transport systems and intracellular electrolyte content we have measured the activity of Na-K ATPase, Na-Li countertransport, as well as red cell sodium and potassium contents in patients with hyperthyroidism and in euthyroid controls. Intracellular Na- and K-concentrations were determined in erythrocytes washed three times in isotonic MgCl2 solution. Ouabain-sensitive Na-transport was estimated as the increase of Na before and after addition of ouabain in an erythrocyte suspension in isotonic Na-free medium. Na-Li countertransport was measured according to the method described by Canessa et al. [2]. The patients with hyperthyroidism exhibited a significantly elevated intracellular sodium content as well as a highly increased Na-K ATPase activity. Intracellular potassium content was not altered in the hyperthyroid subjects, but Na-Li countertransport was markedly decreased as compared to the controls. The results indicate that different ion transport systems of the erythrocyte membrane are influenced by thyroid hormones. We suggest that the elevation of Na-K ATPase activity might be due to the increased intracellular sodium concentration which is caused by the diminished countertransport pathway. Furthermore, the activity of Na-K ATPase, Na-Li countertransport, and intracellular sodium content in erythrocytes might be a useful peripheral indicator of thyroid hormone excess.
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
March 1986,
The Journal of general physiology,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
January 1987,
Hypertension (Dallas, Tex. : 1979),
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
April 1983,
Life sciences,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
August 1978,
The Journal of general physiology,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
April 1998,
Biochimica et biophysica acta,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
May 1987,
Hypertension (Dallas, Tex. : 1979),
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
July 2000,
Kidney international,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
January 1992,
Child nephrology and urology,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
March 1988,
Journal of hypertension,
U Sütterlin, and
K H Gless, and
K Schaz, and
M Hüfner, and
V Schütz, and
W Hunstein
March 2008,
American journal of hypertension,
