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Basal plasma renin activity (PRA) was not modified by pertussis toxin administration. On the contrary, the modulation of PRA by adrenergic amines was markedly affected by the toxin. Administration of epinephrine did not modified PRA in the controls but markedly increased it in toxin-treated rats. This effect of epinephrine was reproduced in control rats when yohimbine was given before the catecholamine. Clonidine decreased PRA to a much more significant extent in control rats than in animals treated with the toxin. Isoproterenol stimulated PRA to a greater level in toxin-treated rats. Our data indicates that pertussis toxin blocks the alpha 2-adrenergic modulation of renin release and magnifies the ability of beta adrenergic activation to stimulate PRA.
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
November 1984,
Infection and immunity,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
November 1973,
Sbornik lekarsky,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
February 1972,
The Journal of clinical endocrinology and metabolism,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
April 1987,
Infection and immunity,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
February 1973,
Casopis lekaru ceskych,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
May 1977,
Nihon Jinzo Gakkai shi,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
January 1971,
Acta physiologica latino americana,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
January 1978,
Nephron,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
January 1977,
Arzneimittel-Forschung,
J Pedraza-Chaverrí, and
M C Alatorre-González, and
M E Ibarra-Rubio, and
J C Peña, and
J A García-Sáinz
April 1972,
The Journal of clinical endocrinology and metabolism,
