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An in vivo characterization of specific central type benzodiazepine (BZD) binding sites, labelled with [11C]Ro 15-1788 was performed, using positron emission tomography. After i.v. injection of 10 mCi [11C]Ro 15-1788 (corresponding to 1 nmol/kg), sequential quantitative tomographic slices of the brain were obtained during 80 min. In some experiments various doses of different cold drugs (BZD agonist or antagonist) were injected i.v. subsequently in order to explore the specificity of the binding of the radioligand in brain structures. The main criteria usually utilized in vitro to demonstrate a specific binding to receptors, such as regional distribution, stereospecificity and saturability of the binding and pharmacological effect linked to the receptor's occupancy, were demonstrated in the brain of a living baboon.
P Hantraye, and
M Kaijima, and
C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
March 1991,
Neuropharmacology,
P Hantraye, and
M Kaijima, and
C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
January 1986,
Acta radiologica. Supplementum,
P Hantraye, and
M Kaijima, and
C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
November 1990,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
P Hantraye, and
M Kaijima, and
C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
March 1995,
Archives of neurology,
P Hantraye, and
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January 1996,
European journal of pharmacology,
P Hantraye, and
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D Comar, and
M Maziere
January 1983,
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie,
P Hantraye, and
M Kaijima, and
C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
March 1988,
Brain research bulletin,
P Hantraye, and
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C Prenant, and
B Guibert, and
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D Comar, and
M Maziere
August 1995,
Annals of neurology,
P Hantraye, and
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C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
January 1985,
Neurology,
P Hantraye, and
M Kaijima, and
C Prenant, and
B Guibert, and
J Sastre, and
M Crouzel, and
R Naquet, and
D Comar, and
M Maziere
March 1992,
European journal of pharmacology,
