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Rat medial basal hypothalami (MBH) or neurointermediate lobes of the hypophysis (NIL) were superfused in vitro and stimulated electrically. The evoked release of vasopressin from the MBH was enhanced to 700% of controls when the tissue was taken from adrenalectomized rats. By contrast, the evoked release of vasopressin from the NIL was not changed after adrenalectomy. After bilateral lesions of the paraventricular nuclei, the evoked release of vasopressin from the MBH was reduced in subsequent in vitro experiments. The marked changes in vasopressin release occurred in spite of no or only small changes in the total tissue content of vasopressin. These data support the view that vasopressin may be released from the external layer of the median eminence into the hypophysial portal blood after activation of the hypothalamo-pituitary-adrenal axis.
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
February 1985,
Brain research,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
April 1982,
Brain research,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
December 1996,
Neuropeptides,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
January 1991,
Neuroscience and behavioral physiology,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
October 1980,
European journal of pharmacology,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
February 1982,
Neuroendocrinology,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
June 1979,
Cell and tissue research,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
January 1993,
Regulatory peptides,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
September 1991,
Brain research,
W Knepel, and
D Nutto, and
D K Meyer, and
M Vlaskovska
November 1995,
Proceedings of the National Academy of Sciences of the United States of America,
