-transparent.png){kind=logo}
The influence of forskolin, an adenylate cyclase activator, and of dibutyryl cyclic AMP (Bt2cAMP) on [3H]glycerol incorporation into glycerolipids was investigated in human platelets. It was found that preincubation with 2.5 mM Bt2cAMP produced a 2-4-fold increase in thrombin-induced incorporation into phospholipids compared to platelets activated by thrombin alone. Pretreatment with forskolin, which increased cellular cAMP content, also resulted in an increase in thrombin-stimulated [3H]glycerol incorporation into phospholipids. These findings demonstrate that a rise in platelet cAMP can accentuate thrombin-induced de novo synthesis of phospholipids from [3H]glycerol. Since the content of cellular cAMP was correlated with its ability to inhibit platelet activation monitored by serotonin release, it seems likely that glycerolipid, in particular phospholipid biosynthesis, is involved in controlling platelet activation by thrombin.
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
January 1985,
Medical biology,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
June 1984,
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
September 1988,
Experimental neurology,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
March 1992,
Journal of neurochemistry,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
September 1973,
The American journal of pathology,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
April 1985,
The Journal of pharmacology and experimental therapeutics,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
October 1983,
Thrombosis research,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
December 1988,
Journal of neurochemistry,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
July 1975,
The Tohoku journal of experimental medicine,
A Imai, and
H Hattori, and
M Takahashi, and
S Nakashima, and
Y Okano, and
T Hattori, and
Y Nozawa
November 1983,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
