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The effects of perioperative antibiotic prophylaxis in elective colon surgery was evaluated in a prospective study on 100 patients. Bowel cleansing was done by orthograde lavage. The patients were divided into 5 groups receiving equally cefotaxime 3 x 2 g, lamoxactam 3 x 2 g, cefmenoxime 3 x 1 g, mezlocillin 3 x 5 g an piperacillin 3 x 4 g. Mucosa biopsies of the resected colon were taken for aerobic and anaerobic cultures. Further mucosal serum probes were frozen immediately for determination of tissue and serum levels of the antibiotics. Our results show that bacterial growth of the colon mucosa was significantly reduced. Anaerobes were identified in only 8%. The tissue concentrations exceeded the MIC-levels of the identified bowel organisms many times over. The clinical infection rate was 4%. All administered antibiotics can be recommended without reservation.
P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
January 1988,
Drugs,
P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
October 2011,
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P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
September 1993,
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P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
April 2002,
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P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
January 1993,
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P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
November 1984,
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P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
January 1988,
Drugs under experimental and clinical research,
P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
August 1984,
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,
P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
January 2003,
Surgical infections,
P Kujath, and
H P Bruch, and
E Schmidt, and
W Döll
April 1998,
The Journal of hospital infection,
