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A fluorometric assay for the cytochrome P-450-dependent enzyme system, aryl hydrocarbon hydroxylase (AHH), was performed in mitogen-activated human lymphocytes from over 300 different humans and from 64 baboons. Results reveal: a) an average interindividual variation in AHH activity of approximately 0.25 (coefficient of variation); range of activities among humans and baboon subjects of approximately 40-fold; c) both genetic and environmental determinants of interindividual variation, and d) high AHH activity in humans associated with primary lung cancer. Confirmation of these results awaits the development of improved methods for phenotyping humans and for prospective cancer patient studies. DNA probes might be employed in future studies to determine specific mRNA content, and to search for DNA polymorphisms in and near the human cytochrome P-450 gene.
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
November 1979,
Cancer research,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
July 1978,
Life sciences,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
July 1973,
Cancer research,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
August 1976,
Biochemical genetics,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
May 1973,
American journal of human genetics,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
January 1982,
Toxicology,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
July 1981,
Cancer research,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
June 1977,
Cancer research,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
December 1976,
Cancer research,
R E Kouri, and
C E McKinney, and
A S Levine, and
B K Edwards, and
E S Vesell, and
D W Nebert, and
T L McLemore
May 1976,
Biochemical and biophysical research communications,
