BIOMAT Database Logo BIOMAT Database Logo

Exogenous vasopressin reverses hyperactivity in the hypothalamus of Brattleboro rats. 1984

T L Krukoff, and F R Calaresu

We have previously described an increase of cytochrome oxidase (COX) activity in discrete hypothalamic nuclei of the Brattleboro rat (BR). The present experiments were done to investigate whether this increase in COX activity could be eliminated by administration of exogenous arginine vasopressin (AVP). Continuous infusion of AVP to BR for 7 days corrected the polyuria and the urine hypoosmolality, as expected, and it also eliminated the COX hyperactivity in the paraventricular nucleus and nucleus circularis of the BR hypothalamus. These results suggest that the hyperactivity of these nuclei in the BR is directly related to their inability to produce AVP.

UI MeSH Term Description Entries
D008297 Male Males
D010286 Paraventricular Hypothalamic Nucleus Nucleus in the anterior part of the HYPOTHALAMUS. Hypothalamic Paraventricular Nucleus,Paraventricular Nucleus,Hypothalamic Nucleus, Paraventricular,Nucleus, Hypothalamic Paraventricular,Nucleus, Paraventricular,Nucleus, Paraventricular Hypothalamic,Paraventricular Nucleus, Hypothalamic
D011910 Rats, Brattleboro A mutant strain of Rattus norvegicus used in research on renal function and hypertension and as a disease model for diabetes insipidus. Brattleboro Rats
D011922 Rats, Mutant Strains Rats bearing mutant genes which are phenotypically expressed in the animals. Mutant Strains Rat,Mutant Strains Rats,Rat, Mutant Strains,Strains Rat, Mutant,Strains Rats, Mutant
D003576 Electron Transport Complex IV A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane. Cytochrome Oxidase,Cytochrome aa3,Cytochrome-c Oxidase,Cytochrome Oxidase Subunit III,Cytochrome a,a3,Cytochrome c Oxidase Subunit VIa,Cytochrome-c Oxidase (Complex IV),Cytochrome-c Oxidase Subunit III,Cytochrome-c Oxidase Subunit IV,Ferrocytochrome c Oxygen Oxidoreductase,Heme aa3 Cytochrome Oxidase,Pre-CTOX p25,Signal Peptide p25-Subunit IV Cytochrome Oxidase,Subunit III, Cytochrome Oxidase,p25 Presequence Peptide-Cytochrome Oxidase,Cytochrome c Oxidase,Cytochrome c Oxidase Subunit III,Cytochrome c Oxidase Subunit IV,Oxidase, Cytochrome,Oxidase, Cytochrome-c,Signal Peptide p25 Subunit IV Cytochrome Oxidase,p25 Presequence Peptide Cytochrome Oxidase
D003919 Diabetes Insipidus A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014667 Vasopressins Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure. Antidiuretic Hormone,Antidiuretic Hormones,beta-Hypophamine,Pitressin,Vasopressin,Vasopressin (USP),Hormone, Antidiuretic,beta Hypophamine
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

T L Krukoff, and F R Calaresu
Exogenous vasopressin modulates activity of oxytocin neurons in homozygous Brattleboro rats.
November 1986, The American journal of physiology,
T L Krukoff, and F R Calaresu
Cathepsin L immunoreactivity in the hypothalamus of normal, streptozotocin-diabetic and vasopressin-deficient Brattleboro rats.
March 1994, Cellular and molecular biology (Noisy-le-Grand, France),
T L Krukoff, and F R Calaresu
Malignant hypertension in Brattleboro (vasopressin-deficient) rats.
June 1983, Journal of hypertension,
T L Krukoff, and F R Calaresu
Vasopressin and deoxycorticosterone hypertension in Brattleboro rats.
January 1982, Annals of the New York Academy of Sciences,
T L Krukoff, and F R Calaresu
Angiotensin immunoreactivity in vasopressin cells in rat hypothalamus and its relative deficiency in homozygous Brattleboro rats.
January 1982, Annals of the New York Academy of Sciences,
T L Krukoff, and F R Calaresu
The behavior of vasopressin-deficient rats (Brattleboro strain).
January 1983, Physiology & behavior,
T L Krukoff, and F R Calaresu
Expression of exogenous vasopressin mRNA by magno-cellular neurons of the supraoptic and paraventricular nuclei in Brattleboro rats.
June 1992, Annals of the New York Academy of Sciences,
T L Krukoff, and F R Calaresu
Atrial natriuretic peptide in plasma, atria, ventricles, and hypothalamus of Long-Evans and vasopressin-deficient Brattleboro rats.
May 1989, Endocrinology,
T L Krukoff, and F R Calaresu
Endogenous vasopressin and the weaning period in Brattleboro rats.
January 1986, Physiology & behavior,
T L Krukoff, and F R Calaresu
Atypical Social Development in Vasopressin-Deficient Brattleboro Rats.
January 2016, eNeuro,
Copied contents to your clipboard!